PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Math Anxiety:Making Room to BreatheValerie Allen (bio) and Todd Stambaugh (bio)"Don't do that to me, Professor," the student said, and everybody laughed, for by this late in the semester, the atmosphere was relaxed. The instructor in question had just reached the point in a worked problem when they could move from reasoning about specific numbers to stating a general principle: x≤y≤z, meaning that y—the value we sought—was always (...) going to be greater than or equal to one value (x) and less than or equal to the other (z). The student who had spoken had earned everyone's affection over the weeks, open about their difficulties with math, ready to risk being wrong, and to ask obvious questions that others may have been reluctant to owning. They had hung in there, despite presenting a classic case of math anxiety, a syndrome long recognized in the scholarship of teaching and learning.Among math anxiety's many symptoms, breathing disruption ranks high: hyperventilation (rapid breathing) and hypoventilation (barely or not breathing). When the energy-conserving parasympathetic nervous system is overtaken by the energy-expending sympathetic nervous system, the long exhalations that decelerate the heart rate are replaced by short, panting puffs from the upper lungs. The timed test provides the perfect environment for math anxiety to flourish. Stress diverts cognitive resources needed for procedural execution, so working memory consequently shrinks.Self-rated metrics for math anxiety have been in place for decades (Richardson and Suinn). Relatively trivial interventions can yield nontrivial results: deep breathing exercises and positive affirmations have a beneficial impact, as does writing about one's nerves immediately prior to an exam (Brunyé et al.). More systemic changes require a reorientation in teaching whereby conceptual mistakes are positively rewarded as opportunities for learning; students compose questions instead of answers; students solve problems together rather than perform solo (Boaler).Return now to that opening scenario to watch it become stereotype incarnate: the student was mature, Black, and female; the teacher, younger, white, and male; her comment was triggered by his shift from a specific [End Page 217] set of numbers into symbolic notation. There is robust evidence to demonstrate that certain demographics are consistently underrepresented in the U.S. math community: women and "African-Americans, Hispanics, American Indians, Alaska Natives, and Pacific Islanders," according to the Mathematical Association of America (MAA) ("Resources for Minority"). Routinely feeling that they do not belong, such groups are particularly vulnerable to math anxiety.Several remedies for such disparity suggest themselves: appointing more women and people of color in the profession; one-on-one tutorial assistance; research projects about the students' personal environment; privileging pre-test, low-stakes work over timed tests; assigning group rather than individual work. When all is said and done, however, such strategies "have little to do with mathematics content" (Martin 304). Mathematicians still need to be able to conceptualize, describe, and manipulate abstract objects, and there seems to be a suspicion that, at heart, abstraction is gendered masculine and colored white.It is possible that the rhetorical immediacy and context-dependence of Black English has misguidedly reinforced such a perception. For poet June Jordan, Black English "devolves from a culture that abhors all abstraction" (Jordan 367). Psychiatrist Alvin Poussaint asks, "Is there a way to say metamorphosis in Ebonics?" (O'Malley). Yet, despite Black English's avoidance of nominalization and similar verbosities that afflict academic prose, abstract logical reasoning flourishes in vernacular idiom, as linguist William Labov demonstrated half a century ago. Our aim is not to explain the asymptote in Black English but rather to consider a feature characteristic of those very minority cultures historically underrepresented in math—storytelling—and to ask how it may be foregrounded in mathematics, where it is decisively sidelined. Storytelling has been claimed by every culture and ethnic group at some point as the repository of wisdom, practical skills, religious beliefs, and shared identity and values; but when it gets corralled into the category of "fiction," and when it gets opposed to "fact," a narrowed concept of truth dispatches storytelling to kindergarten and recreational math. Word problems may supply scenarios but offer none of a plot's satisfactions... (shrink)

Herodotus tells us in book vii, ch. 220, that the Pythian priestess gave the Spartans a warning couched in hexameters, of which the second line begins ἢ μγα στυ ρικυδς. To this text the admirable commentary of How and Wells takes exception in the following note: ‘The synizesis στυ ρικυδς is intolerable. Read δμ' ρικυδς, στυ being a gloss, H. Richards, Cl. Rev. xix. 345.’ Doubtless this union of vowels is harder than that of υω in ρινων or in γενων (...) and δυωδεκμηνον, accepted by Christ in his edition of Pindar . Let us grant that from the point of view of elegance it is even intolerable; the question still remains, should the line be altered? (shrink)

‘Saepe stilum vertas’, says Horace; and he had excellent company in his friend Virgil, who wrote the Aeneid at the rate of only about 900 lines a year, and spent hours in licking his verses into shape. It would have been instructive to sit at the elbow of these two poets, to see what they altered and what they rejected. It is clear, e.g., that there were certain caesural arrangements which Virgil deliberately affected and others which he as deliberately avoided. (...) But what of the care taken by these and other classical authors in arranging sounds in relation to mood or idea? This present incomplete essay is written frankly with scepticism in regard to dogmatic comments on certain particular points. It has been perilously easy to frame legislation on the basis of a predilection bolstered up by one or two instances. Even in the field of syntax we have seen generalizations on too narrow a foundation. An editor of Andocides enunciates ‘a very important principle of the language, which is rigidly observed by the best writers; viz., that, when a participle and a verb of different government are referred to the same object, the case of that object depends on the participle and not at all on the verb… Shilleto's remarks on this point must be excused, as evidently written hastily.’ But a casual cast of the net brings up about a score of violations of this principle from Homer to Menander. Where does the editor propose to draw the line between the respectable and the declassé Greek writers? Aristophanes, though cited in support, is actually flagrantly lawless in the matter; and with him must go not only Homer and Hyperides but Sophocles, Euripides, Menander, Xenophon, Lysias, and Plato, leaving among the élite, as cited by this editor, only Thucydides, Antiphon, and Aeschines; and one is entitled to doubt even their rigid observance of the law until they have actually been brought to court. In problems of rhythm, also, one has to be careful to use evidence as against preconception. When an editor hacks and fits the dactylics of Ennius so as to eradicate all feet beginning with two short syllables, it is as impious as recarving a statue by Daedalus because it does not conform to the canon of Polyclitus; and one may be forgiven if now and then one interprets the editor's corr. in his apparatus criticus not as correxi but as corrupi. (shrink)

On Virgil's statement that in honour of Bacchus ‘Ausonii … coloni versibus incomptis ludunt’, Servius remarks: ‘id est, carminibus Saturnio metro compositis, quod ad rhythmum solum vulgares componere consuerunt….’Obviously Servius is drawing a distinction between the Saturnian and other metres, as well as between the ordinary man and the man of letters. The unlettered compose their verses in the Saturnian metre, which is founded on rhythmus alone; the literary circles write theirs on some other basis.

When Demosthenes brought Aeschines to trial on a charge of malfeasance as an ambassador, he made what seems now the astonishing declaration in connection with Aeschines' acting of the part of Creon in Sophocles' Antigone: ⋯στε γ⋯ρ δ⋯που το⋯θ' ὅτι ⋯ν ἅπασι τοῖς δρ⋯μασι τοῖς τραγικοῖς ⋯ξα⋯ρετ⋯ν ⋯στιν ὥσπερ γ⋯ρας τοῖς τριταγωνισ ταῖς τὺ τοὺς τυρ⋯ννους κα⋯ τοὺς τ⋯ σκ⋯πτρ' ἔχοντας εἰσι⋯ναι. Until the last generation this was taken at face value as indicating that of the three actors presenting a (...) tragedy the third was regularly assigned the part of royalty. But that the title rôle in such plays as Sophocles' Oedipus Tyrannus or an important character such as Creon in the Antigone should have been entrusted to the third ranking actor is incredible. How is the discrepancy to be explained? (shrink)

‘A foolish consistency is the hobgoblin’ not only ‘of little minds,’ but of some classically trained minds as well. And it is surprising to see how this has caused certain unevennesses in ancient authors to be trued up. Aristophanes, for example, we are toldby a late venerable scholar, never permits a change of meter in a single speech directed to the same person; and to get rid of the two deviations from this rule, the framer of it cut down the (...) seemingly good trochaic tetrameters in the Peace to iambic trimeters, and then put line 555 before line 553 and took the three lines 555, 553, 554 from Trygaeus and assigned them to the coryphaeus. It is conceivable that if we possessed the thirty-three lost comedies of Aristophanes the editor might have had more and harder surgery on his hands. (shrink)

We know that microbes contribute to the production of odors that some animals use to communicate, but how common is this phenomenon? Recent studies capitalizing on new molecular technologies are uncovering fascinating associations between microbes and odors of wild animals, but causality is difficult to ascertain. Fundamental questions about the nature of these unique host‐microbe interactions also remain unanswered. For instance, do microbes benefit from signaling associations with hosts? How does microbial community structure influence signal production? How do hosts regulate (...) microbes in order to generate appropriate signals? Here, we review the current state of knowledge on microbially produced signals in animals and discuss key research foci that can advance our understanding of microbial‐based signaling in the animal world. (shrink)

The purpose of this study was to assess the presence of ethics committees in rural critical access hospitals across the United States. Several studies have investigated the presence of ethics committees in rural health care facilities. The limitation of these studies is in the definition of ‘rural hospital’ and a regional or state focus. These limitations have created large variations in the study findings. In this nation-wide study we used the criteria of a critical access hospital (CAH), as defined by (...) the Medicare Rural Hospital Flexibility Program (Flex Program, 2007), to bring consistency and clarity to the assessment of the presence of ethics committees in rural hospitals. The Flex Monitoring Team conducted a national telephone survey of 381 CAH administrators throughout the United States. The survey covered a wide variety of questions concerning hospitals’ community benefit, impact activities, and whether the hospital had a formally established an ethics committee. About 230 (60%) of the respondents indicated they had a formally established ethics committee or ethics consultation program at their CAH. The prevalence of ethics committees declined as the CAH location became increasingly rural along a rural–urban continuum. Unlike CAHs, all rural Department of Veterans Affairs Medical Centers have ethics committees. The results of this study provide an understanding of the limited presence of ethics committee in rural America and the need to consider new approaches for providing ethics assistance. A virtual ethics committee network may be the most efficient and effective way of providing rural hospitals access to a knowledgeable ethics committee or consultant. (shrink)

Many bacteria conditionally express proteinaceous organelles referred to here as microcompartments (Fig. 1). These microcompartments are thought to be involved in a least seven different metabolic processes and the number is growing. Microcompartments are very large and structurally sophisticated. They are usually about 100–150 nm in cross section and consist of 10,000–20,000 polypeptides of 10–20 types. Their unifying feature is a solid shell constructed from proteins having bacterial microcompartment (BMC) domains. In the examples that have been studied, the microcompartment shell (...) encases sequentially acting metabolic enzymes that catalyze a reaction sequence having a toxic or volatile intermediate product. It is thought that the shell of the microcompartment confines such intermediates, thereby enhancing metabolic efficiency and/or protecting cytoplasmic components. Mechanistically, however, this creates a paradox. How do microcompartments allow enzyme substrates, products and cofactors to pass while confining metabolic intermediates in the absence of a selectively permeable membrane? We suggest that the answer to this paradox may have broad implications with respect to our understanding of the fundamental properties of biological protein sheets including microcompartment shells, S‐layers and viral capsids. BioEssays 30:1084–1095, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In the TACITUS project for using commonsense knowledge in the understanding of texts about mechanical devices and their failures, we have been developing various commonsense theories that are needed to mediate between the way we talk about the behavior of such devices and causal models of their operation. Of central importance in this effort is the axiomatization of what might be called commonsense metaphysics. This includes a number of areas that figure in virtually every domain of discourse, such as granularity, (...) scales, time, space, material, physical objects, shape, causality, functionality, and force. Our effort has been to construct core theories of each of these areas, and then to define, or at least characterize, a large number of lexical items in terms provided by the core theories. In this paper we discuss our methodological principles and describe the key ideas in the various domains we are investigating. (shrink)

A discussion of egoism and altruism as related both to ethical theory and moral psychology. Williams considers and rejects various arguments for and against the existence of egoistic motives and the rationality of someone motivated by self-interest. He ultimately attempts to give a more Humean defense of altruism, as opposed to the more Kantian defenses found in Thomas Nagel, for example.

Alterations to cognitive function are often reported with depression and anxiety symptoms, yet few studies have examined the same associations with mental well-being. This study examined the association between mental well-being, depression and anxiety symptoms and cognitive function in 1502 healthy adult monozygotic and dizygotic twins, and the shared/unique contribution of genetic and environmental variance. Using linear mixed models, mental well-being was positively associated with sustained attention, inhibition, cognitive flexibility, motor coordination and working memory, whereas depression and anxiety symptoms were (...) associated with poorer sustained attention, inhibition, cognitive flexibility and executive function. Bivariate twin modelling showed well-being shared a small environmental correlation with motor coordination and a small genetic correlation with working memory. Trivariate twin modelling showed well-being shared a small genetic correlation with inhibition, whereas depression and anxiety symptoms shared a small environmental correlation with inhibition. The remaining variance was mostly driven by unique G and/or E variance. Overall, well-being and depression and anxiety symptoms show both independent and shared relationships with cognitive functions but this is largely attributable to unique G or E variance and small shared G/E variance between pairs of variables. (shrink)

Philosophers usually have been anxious to avoid solipsism. A large number of good and great philosophers have tried to refute it. Of course, these philosophers have not always had the same target in mind and, like everything else, solipsism over the centuries has become increasingly elusive and subtle. In this book I undertake to state the position in its most modern and what I take to be its most plausible form. At some points in the history of philosophy the solipsist (...) has been one who denied the existence of everything except himself or even the existence of everything except his own present sensations. At other times, the solipsist instead of doubting these things has merely insisted that there could be no good reason for believing in the existence of anything beyond one's own present sensations. Roughly, this doubt is aimed at reasons rather than at things. A solipsist of this sort appears in Santayana's Scepticism and Animal Faith. (shrink)

This book offers a compelling new interpretation of James' moral philosophy: an "ethics of responsible self-fashioning." James' performative writing style articulates this conception by showing how moral inquiry serves both social and personal transformation. James the social moral philosopher seeks to create an inclusive moral order through expansion of sympathetic concern among those committed to different ideals. James the existential moral philosopher defends the right to adopt hope-grounding metaphysical beliefs which encourage strenuous moral action in the face of evil and (...) suffering. The power of James' ethics is demonstrated by its application to current discussions about the status of marginalized nonhuman animals and that of the cognitively disabled. William James and the Moral Life is of interest to a wide variety of ethicists and has special appeal to scholars and advanced students in moral philosophy, social philosophy, pragmatism, and American philosophy. (shrink)

An overview of the ancient philosophers and their philosophical system (divided into the fields of logic, physics, and ethics) comprising the living, organic, enduring, and evolving body of interrelated ideas identifiable as the Stoic perspective.

For anyone approaching the Encheiridion of Epictetus for the first time, this book provides a comprehensive guide to understanding a complex philosophical text. Including a full translation and clear explanatory commentaries, Epictetus's 'Encheiridion' introduces readers to a hugely influential work of Stoic philosophy. Scott Aikin and William O. Stephens unravel the core themes of Stoic ethics found within this ancient handbook. Focusing on the core themes of self-control, seeing things as they are, living according to nature, owning one's roles and (...) fulfilling the responsibilities that those roles entail, the authors elucidate the extremely challenging ideas in Epictetus's brisk chapters. Divided into five distinct parts, this book provides readers with: -/- - A new translation of the Encheiridion by William O. Stephens. - A new introduction to ancient Stoicism, its system of concepts, and the ancient figures who shaped it. - A fresh treatment of the notorious and counter-intuitive 'Stoic paradoxes'. - An accessible overview of the origin and historical context of the Encheiridion. - Detailed commentaries on each chapter of the Encheiridion that clarify its recurring themes and highlight their interconnections. - Careful attention to the presentation of the arguments embedded in Epictetus's aphoristic style. - A thoughtful discussion of serious criticisms of Epictetus's Stoicism and replies to these objections. -/- Written with clarity and authority, Epictetus's 'Encheiridion' provides a foundation from which readers can understand this important text and engage with the fundamental questions of Stoic philosophy and ethics. This guide will aid teachers of Epictetus, students encountering Stoicism for the first time, and readers seeking a greater understanding of Stoic ethics. (shrink)

There are two basically different sorts of theory of meaning and the sort of theory one adopts has a great deal to do with the view one takes of the learning of language. Corresponding to the two kinds of theory of meaning two theories of the learning of language are delineated and the issues that are disputed by them clarified. The logical question of whether each theory is intelligible in itself is first discussed, and, it being concluded that both are (...) genuine empirical hypotheses, an examination is made of psychological grounds for preferring one or the other. While no final decision is arrived at, it is argued that there are grounds for preferring one of the theories. (shrink)

In this paper I will argue that Professor Goodman was correct in thinking that there is a problem concerning counterfactual conditionals, but that it is somewhat different from the problem he thought it to be, and is one that is even more basic. I will also try to show that this problem is distinct from Hume's "problem" of induction, and that additional assumptions have to be made for counterfactual induction beyond those required for other kinds of induction.

In early 2020, in-person data collection dramatically slowed or was completely halted across the world as many labs were forced to close due to the COVID-19 pandemic. Developmental researchers who assess looking time were forced to re-think their methods of data collection. While a variety of remote or online platforms are available for gathering behavioral data outside of the typical lab setting, few are specifically designed for collecting and processing looking time data in infants and young children. To address these (...) challenges, our lab developed several novel approaches for continuing data collection and coding for a remotely administered audiovisual looking time protocol. First, we detail a comprehensive approach for successfully administering the Multisensory Attention Assessment Protocol, developed by our lab to assess multisensory attention skills. The MAAP is administered from a distance by using Zoom, Gorilla Experiment Builder, an internet connection, and a home computer. This new data collection approach has the advantage that participants can be tested in their homes. We discuss challenges and successes in implementing our approach for remote testing and data collection during an ongoing longitudinal project. Second, we detail an approach for estimating gaze direction and duration collected remotely from webcam recordings using a post processing toolkit and demonstrate its effectiveness and precision. However, because OpenFace derives gaze estimates without translating them to an external frame of reference, we developed a machine learning approach to overcome this limitation. Thus, third, we trained a ML algorithm [] to classify gaze estimates from OpenFace with respect to areas of interest on the participant's screen. We then demonstrate reliability between this approach and traditional coding approaches. The combination of OpenFace and ML will provide a method to automate the coding of looking time for data collected remotely. Finally, we outline a series of best practices for developmental researchers conducting remote data collection for looking time studies. (shrink)

I show that in Epictetus’ view (1) the wise man genuinely loves (στέργειv) and is affectionate (φιλόστoργoς) to his family and friends; (2) only the Stoic wise man is, properly speaking, capable of loving—that is, he alone actually has the power to love; and (3) the Stoic wise man loves in a robustly rational way which excludes passionate, sexual, ‘erotic’ love (’έρως). In condemning all ’έρως as objectionable πάθoς Epictetus stands with Cicero and with the other Roman Stoics, Seneca and (...) Musonius Rufus, and against the Greeks of the early Stoa. Epictetus’ conception of love excludes erotic passion because of its intrinsic excessiveness and uncontrollableness, which inevitably endanger mental serenity, but includes and emphasizes the soberly rational, purely positive joy of interpersonal affiliation. Epictetus’ account of how the Stoic Sage loves is, I think, more consistent and less problematic than that of the Greek Stoics. (shrink)

The impact of Stoicism on Roman culture and early Christianity was considerable. Unfortunately, little survives of the early writings on Stoicism. Our knowledge of it comes largely from a few later Stoics. In this unique book, William O. Stephens explores the moral philosophy of the late Stoic Epictetus, a former slave and dynamic Stoic teacher. His philosophy, as recorded by one of his students, is the most earnest and most compelling defense of ancient Stoicism that exists. Epictetus' teachings dramatically capture (...) the optimistic spirit of Stoicism by examining our greatest human challenges, such as the death of a loved one. Stephens shows how, for Epictetus, happiness results from concerning ourselves with what is up to us while not worrying about what is beyond our control. He concludes that the strength of Epictetus' philosophy lies in his conception of happiness as freedom from anger, fear, worry, grief, and dependence upon luck. (shrink)

The ancient Stoics believed that virtue is the only true good and as such both necessary and sufficient for happiness. Accordingly, they classified food as among the things that are neither good nor bad but "indifferent." These "indifferents" included health, illness, wealth, poverty, good and bad reputation, life, death, pleasure, and pain. How one deals with having or lacking these things reflects one’s virtue or vice and thus determines one’s happiness or misery. So, while the Stoics held that food in (...) itself contributes nothing to a person’s happiness, how one obtains, prepares, and serves it, and both what and how one eats, all reveal a person’s character as good or bad. Thus, understanding the purpose of food, the necessity of frugality, and the virtue of temperance are all important in Stoicism. This paper traces the ethical views on food from Zeno of Citium and Chrysippus to Seneca, Musonius Rufus, Epictetus, and Marcus Aurelius. They agree that the wise and temperate know that simple, inexpensive foods in moderate amounts produced locally are easy to get and prepare, healthy for the body, and good for the mind. Thus, Stoicism dictates frugality of diet and the rejection of ambitious eating, gluttony, luxuries, delicacies, and gustatory extravagance. Some Stoics favor vegetarianism. All Stoics think it wise to limit eating and drinking to strict bodily need and to eradicate all food anxieties. (shrink)

In a seminal article, Simo Knuuttila and Anja Inkeri Lehtinen drew attention to a “curious doctrine” holding that contradictories can be true at the same temporal instant, and identified the major defenders of the doctrine as John Baconthorpe, Landolfo Caracciolo, and Hugh of Novocastro. Normann Kretzmann later asserted as fact the suggestion by Knuuttila and Inkeri Lehtinen that the doctrine comes from a misreading of a passage from Aristotle’s Physics. In fact, a study of the relevant texts reveals that Hugh (...) of Novocastro first elaborated the doctrine by building on the Scotist doctrines of synchronic contingency and simultaneous causation. As these doctrines require at the same instant of time an order of priority and posteriority between possibility and actuality, cause and effect, so, Hugh says, there must be prior and posterior different states of affairs. Landolfo Caracciolo made this doctrine notorious outside the Franciscan convent by using it in his principia debates, directly engaging the circle of Cardinal Iacopo Stefaneschi. John Baconthorpe, the first to cite the Physics passage, did not have any noticeable effect on the development of the doctrine. (shrink)